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Joseph Bennett
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Clindamycin Phosphate Buy Online [UPDATED]

Vaginal clindamycin is used to treat bacterial vaginosis (an infection caused by an overgrowth of harmful bacteria in the vagina). Clindamycin is in a class of medications called lincomycin antibiotics. It works by slowing or stopping the growth of bacteria. Vaginal clindamycin cannot be used to treat vaginal irritation caused by yeast infections or by sexually transmitted diseases such as chlamydia and trichomoniasis.

clindamycin phosphate buy online

Vaginal clindamycin comes as a suppository to place in the vagina and a cream to apply to the inside of the vagina. The vaginal suppositories are usually used once a day, preferably at bedtime, for 3 days in a row. Most brands of the vaginal cream are used once a day, preferably at bedtime, for 3 days in a row or for 7 days in a row. One brand of vaginal cream (Clindesse) is usually used as a single dose, given at any time of day. If you are using more than one dose of vaginal clindamycin, use it at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Use vaginal clindamycin exactly as directed. Do not use more or less of it or use it more often than prescribed by your doctor.

Use vaginal clindamycin until you finish the prescription, even if you feel better. If you stop using vaginal clindamycin too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online ( ) or by phone (1-800-332-1088).

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Clindamycin is a semi-synthetic lincosamide antibiotic used in the treatment of a variety of serious infections due to susceptible microorganisms14,13 as well as topically for acne vulgaris.12 It has a relatively narrow spectrum of activity that includes anaerobic bacteria as well as gram-positive cocci and bacilli and gram-negative bacilli.8 Interestingly, clindamycin appears to carry some activity against protozoans, and has been used off-label in the treatment of toxoplasmosis, malaria, and babesiosis.9

In oral and parenteral formulations, clindamycin is indicated for the treatment of serious infections caused by susceptible anaerobic bacteria, as well as susceptible staphylococci, streptococci, and pneumococci.14,15 Used topically, it is indicated for the treatment of acne vulgaris12,18,16 and is available in combination with benzoyl peroxide10 or tretinoin11 for this purpose. Clindamycin is also indicated as a vaginal cream13, suppository17, or gel22 for the treatment of bacterial vaginosis in non-pregnant females.

Clostridium difficile associated diarrhea (CDAD) has been observed in patients using clindamycin, ranging in severity from mild diarrhea to fatal colitis and occasionally occurring over two months following cessation of antibiotic therapy.15 Overgrowth of C. difficile resulting from antibiotic use, along with its production of A and B toxins, contributes to morbidity and mortality in these patients. Because of the associated risks, clindamycin should be reserved for serious infections for which the use of less toxic antimicrobial agents are inappropriate.15

Clindamycin is active against a number of gram-positive aerobic bacteria, as well as both gram-positive and gram-negative anaerobes.14 Resistance to clindamycin may develop, and is generally the result of base modification within the 23S ribosomal RNA. Cross-resistance between clindamycin and lincomycin is complete, and may also occur between clindamycin and macrolide antibiotics (e.g. erythromycin) due to similarities in their binding sites.14

Clindamycin inhibits bacterial protein synthesis by binding to 23S RNA of the 50S subunit of the bacterial ribosome.14 It impedes both the assembly of the ribosome and the translation process.20 The molecular mechanism through which this occurs is thought to be due to clindamycin's three-dimensional structure, which closely resembles the 3'-ends of L-Pro-Met-tRNA and deacylated-tRNA during the peptide elongation cycle - in acting as a structural analog of these tRNA molecules, clindamycin impairs peptide chain initiation and may stimulate dissociation of peptidyl-tRNA from bacterial ribosomes.8

Clindamycin undergoes hepatic metabolism mediated primarily by CYP3A4 and, to a lesser extent, CYP3A5.15 Two inactive metabolites have been identified - an oxidative metabolite, clindamycin sulfoxide, and an N-demethylated metabolite, N-desmethylclindamycin.15

While no cases of overdose have been reported, symptoms are expected to be consistent with the adverse effect profile of clindamycin and may therefore include abdominal pain, nausea, vomiting, and diarrhea. During clinical trials, one 3-year-old child was given a dose of 100 mg/kg daily for 5 days and showed only mild abdominal pain and diarrhea.20 Activated charcoal may be of value to remove unabsorbed drug, but hemodialysis and peritoneal dialysis are ineffective.20 General supportive measures are recommended in cases of clindamycin overdose.20

Acne vulgaris is a common dermatologic problem which could be treated with systemic or topical drugs. More importantly the combination therapy of topical clindamycin and tretinoin is more beneficial for the treatment of mild to moderate stages of acne vulgaris [2].

There are some reported articles in the literature for the determination of clindamycin [3-8] or tretinoin [9,10] alone or via the combination of the two drugs [11] by HPLC and gas chromatography in bulk or in pharmaceutical dosage form. HPLC method has been used in the USP35- NF30 for determination of clindamycin phosphate and tretinoin in separate gel dosage form but no simultaneous method is reported [12]. The literature survey revealed that although there were some spectrophotometric methods for the determination of clindamycin [13,14] or tretinoin [15,16] alone, no validated spectrophotometric method for simultaneous determination of clindamycin and tretinoin was reported. The spectrophotometric technique is a highly preferable method for routine analysis due to its simplicity and economical advantages. Since the spectrophotometric quantitative analysis of two or more compounds with overlapping spectra will likely prove difficult, thus the derivative spectrophotometry is a fairly useful method for analysis of a multi-compound mixture.

To give a clear picture, the absorption spectra of clindamycin phosphate and tretinoin are shown in Figure 2 where the zero-order spectra demonstrated a marked overlapping. As a result, simultaneous determination of two drugs will not be possible by direct measurement of absorbance signals. The first to fourth order derivative spectra of those solutions were obtained in the same range at different Δλ values.

Topical clindamycin will not cure your acne. However, to help keep your acne under control, keep using this medicine for the full time of treatment, even if your symptoms begin to clear up after a few days. You may have to continue using this medicine every day for months or even longer in some cases. If you stop using this medicine too soon, your symptoms may return. It is important that you do not miss any doses.

Billionaire Mark Cuban launched an online pharmacy in January that aims to dramatically slash prices for generic drugs, including treatments for diabetes, cancer, mental health issues and hormone therapy. 041b061a72

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